Anne-Louise Comerford began playing the violin and piano at the age of five. She attended the Sydney Conservatorium High School and completed her degree at the Sydney Conservatorium of Music, studying with Robert Pikler.
She was a founding member of the Australian Chamber Orchestra and won a scholarship to study with Joseph De Pasquale at the Curtis Institute in Philadelphia. During this time she attended the New York String Seminar with Alexander Schneider, and also worked with the Stockholm Ensemble in Sweden.
In 1980, she began studies with Bruno Giuranna at the Nordwestdeutsche Musikakademie in Detmold, Germany, and took part in his masterclasses at the Accademia Chigiana in Siena, Italy.
Anne-Louise Comerford returned to Australia to join the Sydney Symphony Orchestra in 1987. She has previously held the position of Principal Viola in the Melbourne Symphony Orchestra and has appeared as guest principal viola with many other Australian orchestras. She is also active as a chamber musician and has performed with the Australia Ensemble and the Sydney Soloists as well as appearing for Musica Viva, and recording for ABC Classic FM. Anne-Louise Comerford has recorded the viola works of Miriam Hyde and is a regular guest at the Kowmung Music Festival in Oberon.
Anne-Louise Comerford plays a Domenico Degani viola made in Montagnana in 1860.